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Trial of second-generation zanamivir shows promise

first_img The study was conducted according to guidance from Japan’s Pharmaceuticals and Medical Devices Agency, according to the statement from Biota. A parallel phase 2 study, performed elsewhere in Asia, addressed dosing. “The results of both trials will be used to support the international regulatory and development program planned for LANI,” the company said. In the double-blind trial, inhaled CS-8958 administered once was “statistically indistinguishable” from 75 mg of oseltamivir given twice a day for 5 days, Biota reported. The company said that in preclinical studies CS-8958 demonstrated efficacy against H5N1 avian influenza, as well as influenza A and B. Neuraminidase inhibitors are used for flu treatment and prevention. The United States and numerous other countries are stockpiling oseltamivir and zanamivir for use against a potential pandemic flu strain. Though the World Health Organization has recommended oseltamivir as the first-line treatment against H5N1 avian influenza, in May British researchers reporting in the journal Nature found that certain mutations in the H5N1 virus that make it resistant to oseltamivir make it vulnerable to zanamivir. They advised nations not to rely on oseltamivir alone when planning their pandemic antiviral stockpiles. Collins PJ, Haire LF, Lin YP, et al. Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature 2008 Jun 26;453(7199):1258-61 [Abstract] The phase 2 trial of CS-8958 included “several hundred” adult patients who had confirmed, naturally acquired influenza A or B, according to Biota. The study was designed to assess the drug’s safety and efficacy and used fever and symptom resolution as endpoints. In background materials outlining the company’s work on influenza drugs, Biota said the long-acting nature of CS-8958 might allow less frequent dosing and could reduce the storage space needed to stockpile antivirals for future pandemic use. Under a grant from the United States National Institutes of Health, the two companies are at the preclinical development stage for a range of other LANI compounds, Biota said.center_img See also: Biota, the Australian company that developed zanamivir, said in a statement yesterday that it is developing the new drug, a long-acting neuraminidase inhibitor (LANI) named CS-8958, through a joint partnership with Japan-based Daiichi-Sankyo. Biota said it and Daiichi-Sankyo were satisfied with the safety, tolerability, and efficacy data for their LANI and that they will use the results to guide a phase 3 trial that will be conducted during the next northern hemisphere influenza season. The phase 3 study will include subjects from locations in Asia, including Japan, Taiwan, Hong Kong, and Korea. Aug 1, 2008 (CIDRAP News) – Two pharmaceutical companies that are developing a second-generation version of the inhaled antiviral drug zanamivir (Relenza) reported promising phase 2 results showing that one dose was as effective against influenza as a course of oseltamivir (Tamiflu). Jul 31 Biota press releaselast_img read more

Residents in Indonesia hold festivities to celebrate Independence Day despite ban

first_imgResidents in various regions of Indonesia decided to go ahead with festive celebrations for this year’s Independence Day, despite calls from authorities to refrain from doing so amid the COVID-19 pandemic.Traditionally, residents celebrate the holiday, which falls on Aug. 17, by hosting lively events with festivities including traditional games and fun competitions — such as pole climbing, sack racing, cracker eating and cooking competitions — as well as parades.As the COVID-19 health crisis in Indonesia has shown no sign of abating, authorities have banned crowd-pulling activities to celebrate the country’s 75th anniversary. The order was issued over fear that events with large numbers of people could be potential clusters for virus transmission.Many residents, however, opted to ignore the order and went ahead with their plans.Residents of Tulus Harapan housing complex in Surabaya, East Java, for example, decided to uphold tradition by hosting fun competitions, saying it was “for the happiness of the children”.”We don’t want the children to miss the exciting moments from the Independence Day celebration,” said a local figure of the neighborhood, Yetti Indra, on Monday, assuring that the participants would implement health protocols such as wearing a mask and maintaining physical distance.In Bandung, West Java, a parade involving several motorcycle communities was spotted on the city’s main roads on Monday morning. They streamed down the streets on dozens of motorcycles while carrying Indonesian flags. In Medan, North Sumatra, residents reportedly celebrated the country’s anniversary with crowd-pullers on Monday, most of them neglecting the required health protocols. An organizer of an Independence Day event in Medan Johor district, Chaeruddin, said he believed the residents of the area were free from the virus. “So, we feel safe to go ahead with the competitions even though some of us are not wearing masks.”It was a similar scene in Medan Selayang district, Medan. The locals started the competitions at 9 a.m., but most of them were without a face mask.In response, North Sumatra deputy governor Musa Rajekshah said he deplored the decision of those residents to host the events, adding that the number of COVID-19 cases in the region was still high at 3,288 so far. “Please limit activities that involve many people for the safety of all North Sumatra residents,” said Musa. Regional administrations across the country took a relatively safe approach to commemorating the country’s 75th anniversary by organizing flag-hoisting ceremonies attended by only a handful of participants.In South Sulawesi, two ceremonies were held separately at the Makassar City Hall compound on Jl. Ahmad Yani and the official residence of Governor Nurdin Abdullah on Jl. Sungai Tangka in Makassar. The events were attended by only dozens of people, including the flag-hosting team. This year’s celebration was significantly different from last year’s festivities, which involved fanfares in Karebosi Square and Losari Beach with hundreds of participants. In Surakarta, Central Java, the ceremony was attended by a limited number of officials along with five ex-terrorists namely Suparno, Paimin, Chamidi, Bayu Setyono and Marmo to foster their sense of nationalism. (vny)— Andi Hajramurni and Ganug Nugroho Adi contributed to the story from Makassar and Surakarta.Topics :last_img read more

Traffic switch planned for I-74 Thursday

first_imgSunman, In. — The Indiana Department of Transportation will shift all westbound traffic on Interstate 74 between State Road 101/Exit 156 and New Point Exit 143 to the left lane tomorrow (NOV 8) to facilitate removal of concrete barrier wall and placement of pavement markings along the right lane section.INDOT officials anticipate reopening the westbound right lane on Sunday, November 11.The westbound rest area closed this morning (NOV 7). This afternoon the eastbound rest area will reopen.  INDOT officials anticipate reopening the westbound rest area Saturday (NOV 10).Phase II operations along this 12.8-mile section of I-74 are coming to a close for the 2018 construction season in advance of winter weather.Milestone is the prime contractor for this $61 million pavement replacement project from New Point in Decatur County–through part of Franklin County—to State Road 101 in Ripley County. It will build  westbound I-74 lanes in 2019.After Thanksgiving, a subcontractor will begin work at the embankment slide near Western Creek. The geohazard subcontractor will embed soil nails into bedrock, then affix a metal grid overcoated with shotcrete to form a stabilizing wall west of the creek.  This will require closing a short section of eastbound I-74’s right lane and outside shoulder area at mile marker 153.7.last_img read more

Loss a mystery for O’Neill

first_imgMartin O’Neill was at a loss to explain how his Ireland side slipped to a second successive friendly defeat as Turkey left Dublin victorious. O’Neill said: “I have seen it back on the big screen, but it’s pretty blatant, and I think the referee knows that. “However, five minutes into the game, it’s a friendly match, he didn’t apply the rules at the end of it all. It’s a definite penalty and as a consequence if it is a penalty, then it’s an automatic sending off. “That said, deep down it’s game that we wanted to contest and if that had been them case, I suppose you take it, but it was a decision that obviously eventually played an important part in the game. “But I am not overly concerned about it.” Despite the result, O’Neill was able to take positives with the contribution of playmaker Wes Hoolahan a particular high point for the manager. He said: “I thought little Hoolahan played brilliantly for us. He tried to create things for us during the course of the game. “Sometimes some big boots come in and shove him off the ball a little bit, but overall he showed a great determination and great ability to try to manoeuvre it. “He was excellent for us.” The game was watched by a crowd of just 25,191, less than a third of the attendance just a few miles away for One Direction’s concert at Croke Park, although O’Neill was happy enough with the turn out. He said: “I was delighted with the crowd in the sense that it’s hard-earned money at the end of a season. “There were a couple of other attractions on in Dublin tonight – even some of my family were thinking about leaving here and going to One Direction, and that includes my wife!” The Ulsterman said: “I actually thought that we created a lot of chances in the game and I genuinely don’t know how we lost the match. “A combination of things – probably poor finishing, some great saves by the goalkeeper too – but we should have had the game out of sight by half-time. “I thought we played really well. I was just saying in the dressing room, there are big moments in matches where you have to really defend stoutly. “You might go 10 or 15 minutes in the match and you are coasting through and you haven’t been tested. Then when the big moments come, you have to be stronger. “Eventually we conceded two goals tonight when I think that there should have been less danger. “That said, genuinely going forward, I thought we were excellent and somebody is going to earn themselves a fortune by being able to put the ball in the net, an absolute fortune.” Things might have been very different had French referee Ruddy Buquet viewed defender Omer Toprak’s fifth-minute challenge on Shane Long differently. Ireland were convinced they should have been awarded a penalty and Toprak a red card, but crucially Buquet was not. Press Association Goals from Ahmet Ilhan Ozek and substitute Osman Tarik Camdal either side of half-time proved sufficient to hand the visitors a 2-1 win at the Aviva Stadium, with Jon Walters’ 78th-minute strike prompting a late, but ultimately unsuccessful, fightback. However, O’Neill and his players were left to rue missed chances, good goalkeeping and two debatable penalty decisions as the Turks did what Serbia managed to do on Irish soil in March. last_img read more

Cricket News Shikhar Dhawan returning to form crucial for India ahead of Australia tour: Rohit Sharma

first_img For all the Latest Sports News News, Cricket News News, Download News Nation Android and iOS Mobile Apps. New Delhi: Shikhar Dhawan’s blazing 92 and Rishabh Pant’s aggressive 58 gave India a tense six-wicket win over West Indies in Chennai during the third and final Twenty20 International on Sunday. The win not only helped India whitewash the West Indies 3-0, it gave the team plenty of momentum ahead of the tour to Australia.Speaking in the post-match press conference, Indian skipper Rohit Sharma  praised the efforts of Dhawan and Pant, stressing that Dhawan coming back to form was crucial ahead of the series Down Under.Read More |India vs West Indies 3rd T20I: India win by 6 wickets, clinch series“It was important from the team’s perspective and for the players to get some runs ahead of the important Australia tour. Shikhar especially was batting well in the ODI series but he was not able to get big scores. I am glad that he could play a match-winning knock and get some form under his belt before the crucial tour,” Rohit said.Read More | Mithali Raj fifty helps India crush Pakistan in Women’s World T20Prior to his knock in Chennai, Dhawan had failed to cross fifty in the five ODI series which India won 3-1. He struggled even in the first two games but showed his class in the third match to give India victory. Rohit was also full of praise for Pant, who turned the tide towards India with a blazing 38-ball 58, laced with five fours and three sixes.“Rishabh was also hungry to go out and get some runs. It was the perfect situation. We were two down inside the first six overs. There was a bit of pressure as well. They handled it well and it was a match-winning partnership. It is important in the team’s perspective that both these guys got runs,” Rohit said.‘Embarrassed’ by lossOn the other hand, West Indies skipper Carlos Brathwaite admitted that a 3-0 whitewash was “embarrassing” for the two-time World T20 champions.Read More | Pakistan suffer heavy ‘penalty’ in loss to India in Women’s World T20“I mean, three-nought looks bad, and it looks embarrassing for me as captain as well. But the performances and fight we gave and the fact that we came together to use our resources to the best of our abilities was the hallmark for this short series for me. The team morale is up. What we are doing as a group is trying to find the best to use the resources we have. In the first game, we showed our fight, we showed our belief with the ball. In the second game, we were blown away, and in the third game we batted excellently, but the game was taken away from us by a massive partnership. We still fought till the end,” Brathwaite said.Since winning the World T20 in 2016, West Indies have been whitewashed 3-0 three times in Asia, twice to Pakistan and now to India. They even lost to Bangladesh and have tasted defeat in New Zealand, underlining their total weakness across formats.However, there was one bright spot in the West Indies’ batting in Chennai, with Nicholas Pooran smashing 53 off just 25 balls. Brathwaite hailed the youngster and added the future looked positive for the Windies. “As a team that’s what we have — the ability for players to take the game away from the opposition and play a knock such as that (of Pooran). The challenge for us is to do that on a more consistent basis. We know we have three,four match-winners in the side who can blow the opposition away,” Brathwaite said. last_img read more

IHOC : Unselfish Scharfe emerges as scorer, remains humble

first_img Published on February 6, 2012 at 12:00 pm Facebook Twitter Google+ When Syracuse needed to get on the board, it turned to its humble goal scorer. With time winding down in Friday’s contest against Robert Morris and the Orange trailing by two goals, Margot Scharfe stepped up once again.After a Caitlin Roach slap shot was turned away, Scharfe, with her back to the net, collected the puck and spun around in one motion to shoot at the cage for a highlight-reel goal.It was arguably the most impressive goal of the season for Syracuse, but Scharfe didn’t think so.‘Oh God, it was a pretty nice bounce I got,’ Scharfe said. ‘ … I don’t think any of my goals are pretty, so I just have to throw it on the net and hopefully something good happens.’And that’s sums up Scharfe in a nutshell. The sophomore forward performs on the ice but deflects attention off it, minimizing her own accomplishments. Scharfe is tied for the team lead in points with 22, scoring 11 goals and giving out 11 assists. While SU head coach Paul Flanagan and teammates realize how valuable Scharfe has become in her second season, the viable scoring threat remains even-keeled, refusing to acknowledge how important she has been to Syracuse (9-18-3, 0-5-3 College Hockey America) this season.AdvertisementThis is placeholder text‘I don’t know. I think I’ve helped out. I’ve been producing a little more this year, so that helps,’ Scharfe said. ‘But I think I could do a little better in terms of providing for the team.’While Scharfe downplays her crucial role for the Orange this season, her teammates and coaches have no problem describing how much she has meant to the team.Junior Holly Carrie-Mattimoe said without Scharfe’s production this season, the Orange’s results would be ‘devastating.’Flanagan said Scharfe has exceeded his expectations after a freshman campaign in which she netted just seven goals and collected 15 points. Though Flanagan admits Scharfe isn’t the fastest, or most skilled, her intangibles take her a long way.‘She was born with some real good hockey instincts,’ Flanagan said. ‘She does a good job of doing the best she can with what she has.’Scharfe said because she isn’t blessed with a load of natural talent, she tries to anticipate what’s going to happen on the ice.And Scharfe doesn’t just rely on her hockey smarts — she puts in long hours on the ice. She’s usually on the ice before and after practice, and no matter how long she’s out there, Scharfe never lets up.Though Flanagan calls her the Orange’s best all-around player, another distinction she earned is most humble.‘She won’t take credit for anything,’ Flanagan said.Carrie-Mattimoe remembers one time earlier in the season when Scharfe scored on a two-on-one opportunity, and the first thing she did was apologize for not making an extra pass.‘I like to apologize a lot, so I’m trying to stop that,’ Scharfe said.As of late, Scharfe is apologizing less and gaining confidence as the Orange enters its final leg of the season. Her teammates have called her names like ‘superstar’ as a way to break her out of her timid shell. Another way has simply been the play Scharfe has shown on the ice. That’s when she’s most comfortable letting her performance do the talking.And with every puck she deposits in the back of the net, Flanagan sees the confidence growing for a player who was a walk-on entering her freshman year.Scharfe joined the team unheralded. And though her play might not be flashy and she apologizes even when she triumphs, Flanagan wouldn’t have it any other way.‘You just open the door for her and let her play,’ Flanagan said. ‘You hope that the other players are paying attention to her work ethic and her humility as a player and just where it’s gotten her.’dgproppe@syr.edu center_img Commentslast_img read more

Baseball fights off Long Beach State in 11-inning thriller

first_imgFor seven innings, the Trojans fought to find any consistent offense against Long Beach State. For seven innings Dirtbags pitcher John Castro had USC’s lineup on its toes, allowing just six hits and zero runs.“I thought Castro pitched phenomenally well for them today,” head coach Dan Stubbs said. “He had three pitches working and he kept us off balance.”But in a wild Tuesday night game that lasted four hours and featured 11 innings, the first seven frames merely served as prelude. The Trojans needed one major play to get back into the game, and junior Lars Nootbaar provided just that. Down 2-0 in the bottom of the eighth with two outs and a man on second, the center fielder blasted a moonshot that sailed over the right field fence. With that two-run homer, a Trojans’ offense that had been largely dormant up until that point came alive.“Honestly it’s one of the greatest feelings,” Nootbaar said. “Just knowing you squared a ball up, it’s almost as if you didn’t even feel it. It’s one of those things where right at contact, you know it’s going out. Just seeing my teammates enjoy it was really the best part.”While Nootbaar’s home run gave the team a chance to win, solid pitching from a very young rotation kept the Trojans afloat up until that point. Junior Mason Perryman performed admirably — if slightly erratically — in only his fourth career start. He gave up just five hits but also hit three batters, at one point nailing two in a row to load the bases. After four innings, he was replaced by sophomore Quinten Longrie, who gave up one hit in nine outs, with five strikeouts.“We’re relying on a lot of young guys,” Stubbs said. “You think about the pitching that was out there today; I think Mason probably has 25 innings of college experience, Longrie might have 2 or 3 innings of college experience and the other guys have zero. We’re going to be a work in progress a little bit.”With the game tied at two at the top of the ninth, Stubbs made the bold decision to send freshman Austin Manning out to the mound. The lefty looked confident at first, striking out LBSU second baseman Jarron Duran. But then he gave up a double followed by a perfectly executed RBI sacrifice fly to center field. Manning managed to get out of the inning giving up only the one run, but the Trojans once again found themselves in a do-or-die situation heading into the bottom of the ninth.This time, however, they didn’t need Nootbaar’s hot bat. With two freshman pinch runners, John Thomas and Christian Moya, at the corners senior Cris Perez came up to bat with two outs. As Thomas attempted to steal from first base, LBSU catcher David Baneulos overthrew the second baseman, allowing Moya to score off of the error. The Trojans left the inning with a 3-3 tie, meaning that fans at Dedeaux Field would be treated to a late night of extra innings.Both teams failed to score in the 10th inning. Manning produced a three up, three down inning on the defensive end and then senior AJ Fritts was unable to bring junior Adalberto Carrillo home from third with one out.After Manning once again prevented the Dirtbags from scoring in the top of the 11th, the Trojans  seemed destined to finally finish the game. First Brandon Perez reached first base when LBSU’s center fielder dropped a routine flyball. Then he reached second off of a wild pickoff throw to first base. The Dirtbags’ pitcher Chris Rivera intentionally walked Matthew Acosta and Tyler Urbach leaving the bases loaded with zero outs.Despite the odds stacked in their favor, the Trojans still did not make ending the game a simple task. Cris Perez and David Edson both struck out, leaving junior shortstop Frankie Rios up to bat with two outs and the game on the line. Rios immediately got down 0-2 in the count, and for a minute it looked as though USC had squandered another golden opportunity — except it had not. Rios blasted a walk-off single to center field and was immediately mobbed by an army of exhausted teammates.“I was excited,” Rios said. “I wasn’t doing all too well, and then I got that hit. I saw it off the bat, and I was pumped.”On the game, Nootbaar produced a memorable performance, going 3-4 with a home run and two RBI. On the season, he is batting .688 with two homers.A positive sign for USC going forward was the season debut of senior leader Corey Dempster following a knee injury. The outfielder came into the eighth inning as a pinch hitter and singled on the first pitch he saw.After defeating LBSU, the Trojans travel to North Carolina on Friday for games against Wake Forest and Duke.last_img read more

NBA playoffs 2019: Raptors’ Nick Nurse praises Kawhi Leonard’s ‘big-time’ performance

first_imgLeonard stated that the victory was all that mattered to him. “This individual stuff, it’s not big for me,” Leonard said. “To reach these goals, it’s great when you do it and you could win. “But our focus is every game trying to win the ballgame. That’s why we’re playing this game. We’re not playing so I could score 50 or get 40 points; we’re all on this team trying to say, ‘Raptors win’ at the end of the day.” Clinical performance.@TangerineHoops Game HighlightsWatch: https://t.co/uW1LkoBdLv pic.twitter.com/bAvfNwtQ7U— Toronto Raptors (@Raptors) April 28, 2019″A big-time performance at both ends,” he told reporters. “I just like the force he’s playing with at both ends, but especially when he’s getting the ball. “He’s pushing it up the floor. He’s punching the gaps with force. He’s determined to get to spaces. I guess I should not be surprised, but that was pretty cool to watch.”  NBA playoffs 2019: Spurs coach Gregg Popovich ‘surprised people stayed’ for ‘odd’ Game 7 Nick Nurse saluted a “big-time performance at both ends” from Kawhi Leonard after he inspired the Toronto Raptors to a 108-95 victory in Game 1 of their Eastern Conference semifinals series against the Philadelphia 76ers. Leonard scored a career playoff high 45 points and claimed 11 rebounds as the Raptors won at Scotiabank Arena on Saturday. center_img NBA playoffs wrap 2019: Raptors cruise to win; Nuggets outlast Spurs in Game 7 The Raptors superstar also became only the sixth player in NBA history to pour in at least 45 points, grab 11 rebounds and make three or more three-pointers. Raptors head coach Nurse praised the contribution that the outstanding forward made both in attack and defense.  Related Newslast_img read more